Regenerative care for healthier-looking skin
Improve fine lines, texture, elasticity and tired-looking under-eyes with injectable polynucleotides. Treatment is personally planned and performed by Dr Isran Sajid.
A clinician-led approach to polynucleotides
Every polynucleotide treatment begins with a medical consultation.
Dr Isran will assess your skin, anatomy and concerns. He will then decide whether polynucleotides are suitable for you.
Polynucleotides are injectable skin treatments. They are designed to support skin quality and repair without adding defined facial volume.
At Harley Private Medical, treatment is planned and performed by Dr Isran Sajid. Safety and natural-looking results remain the priority.
Improve skin quality without changing your features
Polynucleotides are purified chains of nucleotides. Nucleotides occur naturally within DNA.
When injected into the skin, polynucleotides are designed to support the skin’s repair processes. They may help improve hydration, texture and elasticity over time.
Polynucleotides may help:
✔ Improve fine lines and crepey skin
✔ Support firmer-looking skin
✔ Improve texture and elasticity
✔ Refresh tired-looking under-eyes
✔ Improve dull or dehydrated skin
✔ Support more resilient-looking skin
The aim is not to add volume. Results are subtle and progressive.
How are polynucleotides different?
Polynucleotides focus on skin quality rather than facial volume. They are often used where the skin appears thin, crepey, tired or damaged. This includes the delicate area around the eyes.
Approximately 15 minutes
A relatively quick injectable treatment.
No defined volume
Designed to improve skin quality without reshaping your features.
Suitable for delicate areas
Can be used around the eyes following medical assessment.
Minimal downtime
Small bumps, swelling or bruising may occur.
Personalised placement
Injection points are planned around your anatomy and concerns.
Progressive results
Changes develop gradually over several weeks.
What our patients say
Reflections from people who have visited our clinic and shared their experience.
Our polynucleotide pricing
Face
Improves overall skin quality, hydration, elasticity and the appearance of fine lines.
£249
Neck
Targets crepey texture, fine lines and declining skin quality across the neck.
£249
Under Eyes
Designed for delicate under-eye skin to improve texture, hydration and fine lines.
£249
The treatment process
Polynucleotides are placed into targeted areas using small injections. They are designed to support the skin’s natural repair environment. Improvements develop as the skin responds over time.
1. Medical assessment and treatment planning
Dr Isran will assess your skin and medical history. He will discuss your concerns and expected outcome. He will also check that treatment is appropriate for you.
2. Precisely placed injections
The product is placed using a series of small injections. The technique and injection points depend on the area being treated.
3. Skin-quality support
Polynucleotides are designed to support fibroblast activity and the skin’s extracellular environment. These processes play a role in skin structure, hydration and resilience.
4. Progressive improvement
Changes appear gradually over the following weeks. The skin may look smoother, firmer and more refreshed. Results vary between patients.
Why Harley Private?
Polynucleotide treatment is not simply about the product being injected — how and where it is delivered matters too.
For the delicate under-eye area, Dr Isran uses a microcannula technique, allowing him to carefully distribute polynucleotides across the treatment area through a single entry point on each side, rather than relying on multiple individual needle injections.
This approach is designed to minimise unnecessary trauma to the delicate tissues around the eyes and may help reduce the number of visible injection points, bruising and downtime associated with treatment.
Initial medical assessment and personalised treatment plan
Precisely placed injections tailored to the treatment area
Minimal downtime, with temporary redness, swelling or small bump possible
Gradual improvements in hydration, texture and overall skin quality
Professional aftercare guidance
Review of your progress and future maintenance needs
Polynucleotides vs skin boosters—a transparent comparison
Both treatments can improve skin quality. However, they use different ingredients and have different treatment priorities.
The best option depends on your skin and desired result.
Dr Isran Sajid
GMC: 7561260
MBBS (Distinction), MRCGP (‘22)
Dr Isran Sajid is a GMC-registered medical doctor. He specialises in advanced aesthetic medicine, injectable treatments and full-face rejuvenation.
His approach looks at the skin and facial structure as a whole. Treatments are planned to create balance without overfilling or altering natural features.
Polynucleotide treatment begins with a medical assessment. Dr Isran will consider your anatomy, skin quality and desired outcome.
If another treatment is more suitable, he will explain why. Honest advice, patient safety and natural results remain the priority.
✔ GMC-registered medical doctor
✔ Advanced injectable treatments
✔ Full-face rejuvenation planning
✔ Personalised medical assessment
✔ Natural-results-focused approach
Ready to begin? It starts with a conversation.
Every treatment plan starts with careful assessment and open discussion. A consultation helps ensure decisions are informed, appropriate, and tailored to you.
Frequently asked questions
These frequently asked questions provide general information about SkinPen microneedling and what you may expect from treatment. Your suitability, anticipated results and recommended treatment course will be discussed during your consultation.
What are polynucleotides?
Polynucleotides are injectable regenerative treatments made from purified DNA fragments. They are designed to support the skin’s natural repair processes and improve hydration, elasticity, texture and overall skin quality.
How do polynucleotides work?
Polynucleotides help create an environment that supports fibroblast activity—the cells involved in producing collagen and elastin. Improvements develop gradually as the skin repairs and remodels itself.
Which areas can be treated?
Common treatment areas include the face, under-eyes, neck and décolletage. The areas treated will depend on your skin, concerns and the specific product being used.
Are polynucleotides the same as dermal filler?
No. Polynucleotides focus primarily on improving skin quality and regeneration without significantly changing facial shape or adding volume.
How are polynucleotides different from Profhilo?
Polynucleotides focus on skin repair, resilience and regeneration. Profhilo is a hyaluronic-acid-based treatment primarily used to improve hydration, elasticity and mild skin laxity. Dr Isran will advise which option is more appropriate for your skin.
How many treatments will I need?
Most patients are advised to complete an initial course of treatments, often spaced several weeks apart. The number and timing will depend on the product used, treatment area, skin condition and desired outcome.
When will I see results?
Results develop gradually rather than appearing immediately. Some patients notice improved hydration and skin quality within the first few weeks, with further improvement as collagen and elastin remodelling continues.
How long do the results last?
Longevity varies according to the product used, treatment area, age, lifestyle and individual skin response. Maintenance treatments may be recommended to help preserve the results.
Is the treatment painful?
A series of small injections is required, so brief pinching or stinging may be felt. A topical anaesthetic may be used to make the treatment more comfortable.
Is there any downtime?
Downtime is usually limited, although temporary redness, swelling, tenderness, bruising or small raised bumps can occur around the injection points. These effects normally settle, but recovery varies between patients.
Get in touch with the Harley Private team
If you’d like to book an appointment, have a question about our treatments, or need further information, our friendly team is here to help.
More details:
If you have any questions or would like to speak with our team, we’re here to help.
