Stimulate your skin’s own collagen for gradual, natural rejuvenation
Stimulate your skin’s own collagen for firmer, stronger and naturally rejuvenated skin — with results that develop gradually over time.
A clinician-led, medical approach to biostimulators
Biostimulators are an advanced injectable treatment designed to work with your body rather than simply adding volume.
Unlike traditional dermal fillers, which use hyaluronic acid gel to provide immediate structure and volume, biostimulators encourage your skin to produce more of its own collagen over time. The result is gradual improvement in skin quality, firmness and support, while maintaining a natural appearance.
At Harley Private Medical in Sheffield, biostimulator treatments are performed by Dr Isran Sajid, using Juläine® as part of a personalised approach to facial rejuvenation.
What are biostimulators?
As we age, our natural production of collagen gradually declines. This contributes to changes including thinner skin, reduced elasticity, loss of firmness and changes in facial support.
Biostimulators are injectable treatments specifically designed to stimulate the biological processes involved in collagen production.
Once introduced into targeted areas of the skin, the treatment encourages a regenerative response. Rather than creating an immediate or artificial-looking change, improvement develops progressively as new collagen is produced.
This makes biostimulators particularly suited to patients who want to improve the quality and structure of their skin without looking as though they have had extensive filler treatment.
Why choose Harley Private for biostimulators
Juläine is a collagen biostimulator designed to work with your skin’s natural regenerative processes. Rather than simply adding volume, it stimulates new collagen production to gradually improve firmness, elasticity and tissue support over time.
Stimulates your own collagen
Encourages your skin’s natural regenerative response to produce new collagen and improve tissue quality.
No added facial volume
Designed to improve firmness and support without relying on traditional filler to reshape the face.
Natural-looking results
Changes develop progressively, helping you look refreshed and better supported rather than noticeably “treated”.
Gradual skin remodelling
New collagen develops over the following weeks and months, with results continuing to evolve after treatment.
Doctor-led treatment
Personally assessed and treated by Dr Isran Sajid as part of an individualised facial rejuvenation plan.
Longer-term improvement
Rather than providing a short-term cosmetic effect, Juläine is designed to stimulate regenerative changes within your own tissue.
What our patients say
Reflections from people who have visited our clinic and shared their experience.
Our biostimulator pricing
Face
Stimulates natural collagen production to improve firmness, elasticity and overall skin quality.
£595
Neck
Supports collagen renewal to improve laxity, texture and crepey skin across the neck.
£595
The treatment process
Juläine is an injectable biostimulator designed to stimulate your skin’s own regenerative processes. Rather than simply adding volume, it works progressively by encouraging new collagen production, helping to improve firmness, elasticity and tissue support over time.
1. Medical assessment and treatment planning
Dr Isran begins by assessing your skin, facial structure, medical history and areas of concern. This allows him to determine whether Juläine is appropriate and how biostimulation can best be incorporated into your individual rejuvenation plan.
2. Precisely placed injections
Juläine is carefully introduced beneath the skin in targeted areas according to your anatomy and treatment goals. The technique is designed to distribute the biostimulator through the tissues where collagen stimulation is required.
3. Collagen stimulation begins
Following treatment, Juläine stimulates a regenerative response within the tissue, activating the processes responsible for producing new collagen and supporting proteins.
4. Progressive tissue remodelling
Over the following weeks and months, newly produced collagen gradually remodels and strengthens the tissue. Improvements develop progressively, helping the skin appear firmer, better supported and naturally rejuvenated.
Results and longevity
Juläine is designed to create progressive rather than immediate change. For most new patients, an initial course of at least two treatments approximately 4–6 weeks apart is recommended, allowing each treatment to build upon the regenerative response initiated by the previous session.
Collagen production and tissue remodelling continue after treatment, with results developing gradually over the following months. More meaningful improvements are typically assessed at around 3–5 months, although individual responses vary.
Your treatment will be planned and delivered by Dr Isran Sajid following a full medical assessment. Any additional treatment or future maintenance will be recommended according to your skin, goals and response.
Medical consultation and suitability assessment
Gradual collagen stimulation and tissue remodelling
Treatments approximately 4–6 weeks apart
Personalised treatment planning by Dr Isran Sajid
Clinical advice and aftercare
Biostimulators vs Dermal Filler. Different approaches. Different results.
Dermal filler restores structure directly. Biostimulators encourage your skin to rebuild support gradually through new collagen production.
Dr Isran Sajid
GMC: 7561260
MBBS (Distinction), MRCGP ('22)
Dr Isran Sajid is a GMC-registered medical doctor who has dedicated his career to advanced aesthetic medicine, with a particular focus on injectable treatments and full-face rejuvenation.
With extensive training in dermal fillers, anti-wrinkle treatments and injectable skin treatments, he takes a considered approach to facial aesthetics—looking at the skin, structure and proportions of the face as a whole.
His approach centres on restoring freshness, balance and facial harmony without overfilling or unnecessarily altering a patient’s natural features. Every biostimulator treatment begins with a thorough medical assessment and a personalised plan based on the patient’s skin and individual goals.
At Harley Private Medical, patient safety, honest recommendations and natural-looking results are always the priority.
✔ GMC-registered medical doctor
✔ Advanced injectable treatments
✔ 10,000 Successful Injectable Treatments
✔ Natural-results-focused approach
Ready to begin? It starts with a conversation.
Every treatment plan starts with careful assessment and open discussion. A consultation helps ensure decisions are informed, appropriate, and tailored to you.
Frequently asked questions
These frequently asked questions are designed to provide clear, honest information about biostimulators. If you have further questions, these can be discussed in detail during your consultation.
What is a biostimulator?
A biostimulator is an injectable treatment designed to stimulate biological processes involved in the production of collagen. Unlike traditional dermal filler, its primary purpose is not simply to add immediate volume.
What is Juläine?
Juläine is an injectable biostimulator used at Harley Private Medical to encourage collagen production and gradual improvement in skin quality, firmness and tissue support.
Is Juläine a dermal filler?
No. Although both treatments are injectable, they have different purposes. Dermal fillers provide immediate structural volume, whereas Juläine primarily works by stimulating your body's own collagen response.
How many Juläine treatments do I need?
Most patients will require at least two sessions, generally spaced approximately 4–6 weeks apart. Dr Isran will recommend an individual treatment plan following consultation.
When will I see results?
Some patients notice improved hydration and radiance following their first treatment. Changes in texture, firmness and elasticity generally develop more gradually over the following weeks and may become more noticeable after completing the initial course.
How long does Juläine results last?
The duration of results varies between patients and can be influenced by age, skin quality, lifestyle and the area treated. Dr Isran can recommend an appropriate maintenance schedule based on how your skin responds.
How quickly does Juläine work?
Results develop gradually because your body needs time to produce new collagen. Improvement typically develops over several months, with results commonly assessed around 3–5 months.
Can Juläine be used on the neck?
Yes. Juläine can be used to treat either the face or neck. Treating both areas requires additional product and will therefore be priced separately.
Get in touch with the Harley Private team
If you’d like to book an appointment, have a question about our treatments, or need further information, our friendly team is here to help.
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